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Renes R Machado Selected Research

2-phthalimidethyl nitrate

8/20172-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation.
6/2015Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms.
7/2014Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema.

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Renes R Machado Research Topics

Disease

15Pain (Aches)
02/2022 - 12/2008
12Hyperalgesia
04/2022 - 05/2013
10Inflammation (Inflammations)
02/2022 - 06/2014
9Edema (Dropsy)
04/2022 - 06/2014
7Neuralgia (Stump Neuralgia)
02/2022 - 05/2013
6Fever (Fevers)
03/2011 - 08/2007
5Nociceptive Pain
02/2020 - 10/2013
2Pleurisy (Pleuritis)
02/2022 - 12/2015
2Type 2 Diabetes Mellitus (MODY)
02/2022 - 09/2019
1Sepsis (Septicemia)
04/2020
1Infections
04/2020
1Hypersensitivity (Allergy)
04/2020
1Septic Shock (Toxic Shock Syndrome)
04/2020
1Pneumonia (Pneumonitis)
04/2020
1Rheumatoid Arthritis
01/2018
1Arthritis (Polyarthritis)
05/2009

Drug/Important Bio-Agent (IBA)

9CarrageenanIBA
04/2022 - 06/2014
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2022 - 02/2008
5Naltrexone (ReVia)FDA LinkGeneric
02/2020 - 06/2014
5Formaldehyde (Formol)FDA Link
12/2019 - 05/2013
4Paclitaxel (Taxol)FDA LinkGeneric
04/2022 - 01/2018
4Nicorandil (SG 75)IBA
04/2018 - 05/2013
4Opioid Analgesics (Opioids)IBA
12/2015 - 02/2008
4Indomethacin (Indometacin)FDA LinkGeneric
03/2011 - 08/2007
4ProstaglandinsIBA
03/2011 - 08/2007
4Prostaglandins EIBA
03/2011 - 08/2007
4Celecoxib (Celebrex)FDA Link
05/2009 - 08/2007
3Niacinamide (Nicotinamide)FDA LinkGeneric
02/2020 - 05/2013
3phthalimideIBA
12/2019 - 07/2014
3CytokinesIBA
10/2017 - 10/2008
32-phthalimidethanolIBA
08/2017 - 07/2014
3hydroxide ionIBA
08/2017 - 07/2014
32-phthalimidethyl nitrateIBA
08/2017 - 07/2014
3LipopolysaccharidesIBA
03/2011 - 08/2007
3Ibuprofen (Motrin)FDA LinkGeneric
05/2009 - 08/2007
2Hypoglycemic Agents (Hypoglycemics)IBA
02/2022 - 09/2019
2Metformin (Glucophage)FDA LinkGeneric
02/2022 - 09/2019
2Thiamine (Aneurin)FDA Link
02/2020 - 10/2017
2Vitamin B Complex (B Vitamins)IBA
02/2020 - 10/2017
2Riboflavin (Vitamin B2)FDA LinkGeneric
02/2020 - 10/2017
2Freund's AdjuvantIBA
12/2019 - 10/2017
2glutarimideIBA
12/2019 - 07/2014
2Glyburide (Glibenclamide)FDA LinkGeneric
09/2019 - 04/2018
2Cyproheptadine (Periactin)FDA Link
04/2018 - 06/2014
2Pharmaceutical PreparationsIBA
01/2018 - 10/2013
2Dexamethasone (Maxidex)FDA LinkGeneric
10/2017 - 05/2009
2Narcotic Antagonists (Opioid Antagonists)IBA
12/2015 - 06/2014
2ZymosanIBA
06/2014 - 05/2009
2Minocycline (Cyclops)FDA LinkGeneric
10/2013 - 05/2013
2Dinoprostone (PGE2)FDA Link
05/2013 - 10/2008
2Endothelin-1 (Endothelin 1)IBA
03/2011 - 02/2008
2Dipyrone (Metamizole)IBA
03/2011 - 05/2009
2AntipyreticsIBA
05/2009 - 10/2008
2Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
02/2008 - 08/2007
1CurcuminIBA
04/2022
1Adenosine Triphosphate (ATP)IBA
02/2022
1Potassium Channels (Potassium Channel)IBA
02/2022
1Clindamycin (Cleocin)FDA LinkGeneric
04/2020
1KATP ChannelsIBA
02/2020
1Therapeutic UsesIBA
09/2019
1AMP-Activated Protein KinasesIBA
09/2019
1Hydrogen Sulfide (Sulfide, Hydrogen)IBA
08/2019
14-methylbenzenecarbothioamideIBA
08/2019
1Meloxicam (Mobic)FDA LinkGeneric
04/2018
1Leflunomide (Arava)FDA LinkGeneric
01/2018
1Adrenal Cortex Hormones (Corticosteroids)IBA
10/2017
1methylated bovine serum albumin (MBSA)IBA
08/2017
1ChemokinesIBA
08/2017
1AntigensIBA
08/2017
1Analgesics (Analgesic Drugs)IBA
12/2015
1CannabinoidsIBA
06/2015
1Thalidomide (Thalomid)FDA Link
07/2014
1azadirachtin (azadirachtin A)IBA
06/2014
1Tetracycline (Achromycin)FDA LinkGeneric
05/2013
1TetracyclinesIBA
05/2013
1CationsIBA
05/2013
1Anti-Bacterial Agents (Antibiotics)IBA
05/2013
1Toll-Like Receptors (Toll-Like Receptor)IBA
05/2013
112S-hydroxy-1,12-pyrazolinominocyclineIBA
05/2013
1NitratesIBA
05/2013
1Acetaminophen (Paracetamol)FDA LinkGeneric
05/2009
1Chemotactic FactorsIBA
10/2008
1QuercetinIBA
03/2008
1Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA
02/2008
1Interleukin-6 (Interleukin 6)IBA
02/2008
1Prostaglandins FIBA
02/2008
1mu Opioid Receptors (mu Opioid Receptor)IBA
02/2008
1Morphine (MS Contin)FDA LinkGeneric
02/2008
1PyrogensIBA
02/2008
1CCR5 Receptors (CCR5 Receptor)IBA
08/2007
1Chemokine CCL5IBA
08/2007
1Chemokine ReceptorsIBA
08/2007
1Met- RANTESIBA
08/2007

Therapy/Procedure

2Injections
04/2018 - 10/2017
1Intra-Articular Injections
08/2017
1Analgesia
10/2013
1Subcutaneous Injections
05/2009